Asked by: Nonita Mendia
Asked in category: medical health, hormonal disorders, medical health, hormonal disorders
Last Updated: 19th Apr 2024
What is the history of Klinefelter syndrome?
Dr. Harry Klinefelter, along with his colleagues, first described the combination that would become known as Klinefelter Syndrome in 1942. In the late 1950's, researchers discovered a new sex chromosome in men with this syndrome, XXY, which was not the usual male arrangement.
How does XXY syndrome happen?
Klinefelter syndrome is usually caused by an unplanned event in the formation of reproductive cells (eggs or sperm). Nondisjunction is a mistake in cell division that results in a cell with an abnormally high number of chromosomes.
Klinefelter syndrome can also be inherited from a girl. Klinefelter syndrome, which affects both men and boys, is caused by the presence of an extraX chromosome within cells. people have 46 cells with 46 chromosomes, two of which are sex chromosomes. Males have one X chromosome (46.XXXXX) and females two X chromosomes (46.6,XXXX).
Therefore, what is XXY male gender?
The sex chromosomes determine a person's gender. Females have two Xchromosomes (XXX); males have one Xchromosome and one of the Ychromosomes (XY). Males born with the XXY syndrome have cells with an extra Xchromosome or XXY.
How did Klinefelter's Syndrome get its name?
Klinefelter syndrome, which affects one to two men per 1,000 live births, is one of the most common chromosomal conditions. It was named after Harry Klinefelter an American endocrinologist who first identified the condition in 1940. The extra X chromosome was first identified in 1956.
17 Related Question Answers Found
Is Klinefelter an intersex?
Significantly, Sax did not consider either Klinefelter's or Turner syndrome as intersex, as they are not 'associated with ambiguous genitalia, or with any confusion regarding sexual identity' (177).
Can Xyy have babies?
That is, men with XYY syndrome are not more or less likely than other men to have children with XYY syndrome. The random error can occur during the formation of sperm or at different times during the formation of an embryo. In the latter case, a male may have some cells that are not affected.
Can a man with Klinefelter syndrome have babies naturally?
It is possible that an XXY male could get a woman pregnant naturally. A few men with KS have recently been able to father a biologically related child by undergoing assisted fertility services, specifically, a procedure called testicular sperm extraction with intracytoplasmic sperm injection (TESE-ICSI).
How does Klinefelter syndrome affect a person's life?
Klinefelter syndrome can cause problems with learning and sexual development in guys. It's a genetic condition (meaning a person is born with it). Klinefelter syndrome only affects males. That doesn't make a guy less male, but it can affect things like penis and testicle growth, and growth of body hair and muscles.
Is Klinefelter syndrome a disability?
Klinefelter syndrome is a genetic condition that occurs in males of all racial and ethnic backgrounds. It affects sexual development and may lead to learning disabilities. Klinefelter syndrome occurs in about 1 in 500 to 1 in 1,000 boys. Learning: Most boys with Klinefelter syndrome have normal intelligence.
How long is the average lifespan of a person with Klinefelter syndrome?
According to research, Klinefelter syndrome can shorten your life expectancy up to two years. However, you can still live a long, full life with this condition. The earlier you get treatment, the better your outlook will be.
Who is responsible for baby gender?
Men determine the sex of a baby depending on whether their sperm is carrying an X or Y chromosome. An X chromosome combines with the mother's X chromosome to make a baby girl (XX) and a Y chromosome will combine with the mother's to make a boy (XY).
Are XXY males infertile?
Treatment for Infertility
Between 95% and 99% of XXY men are infertile because they do not produce enough sperm to fertilize an egg naturally. But, sperm are found in more than 50% of men with KS. For instance, it is possible that the resulting child might have the XXY condition.What part of the body does Klinefelter syndrome affect?
Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue.
Can you be a girl with a XY chromosome?
In this system, the sex of an individual is determined by a pair of sex chromosomes. Females typically have two of the same kind of sex chromosome (XX), and are called the homogametic sex. Males typically have two different kinds of sex chromosomes (XY), and are called the heterogametic sex.
How common is Xyy?
XYY syndrome is a rare chromosomal disorder present at birth that affects only males. It is estimated to occur in approximately one in 1,000 live births.
Can you be born with XXY chromosomes?
Klinefelter syndrome is a genetic condition in which a boy is born with an extra X chromosome. Instead of the typical XY chromosomes in men, they have XXY, so this condition is sometimes called XXY syndrome. Men with Klinefelter usually don't know they have it until they run into problems trying to have a child.
Is XXY a mutation?
Less commonly, some woman are found to be 47, XXY. In most of these cases, a change or mutation has been found in a gene that helps control male sexual development. Most often, women with 47, XXY are infertile, but in a few cases they have had children naturally.
What happens if you have 2 extra chromosomes?
Cells with two additional sets of chromosomes, for a total of 92 chromosomes, are called tetraploid. A condition in which every cell in the body has an extra set of chromosomes is not compatible with life. In some cases, a change in the number of chromosomes occurs only in certain cells.
What are the types of syndromes?
How can I find out more about specific genetic syndromes?
- YourChild: Angelman Syndrome.
- Cri du Chat Syndrome (5 P-)
- YourChild: Down Syndrome (Trisomy 21)
- YourChild: Fragile X Syndrome.
- Klinefelter Syndrome.
- YourChild: Neurofibromatosis.
- YourChild: Prader-Willi Syndrome.
- YourChild: Rett Syndrome.
What is Trisomy 23?
Summary. Humans have 23 pairs of chromosomes. A trisomy is a chromosomal condition characterised by an additional chromosome. A person with a trisomy has 47 chromosomes instead of 46. Down syndrome, Edward syndrome and Patau syndrome are the most common forms of trisomy.
Is Klinefelter syndrome curable?
Currently, there is no way to remove chromosomes from cells to "cure" the XXY condition. But many symptoms can be successfully treated, minimizing the impact the condition has on length and quality of life.
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